One‐Hz repetitive transcranial magnetic stimulation of the premotor cortex alters reciprocal inhibition in DYT1 dystonia
Identifieur interne : 003C31 ( Main/Exploration ); précédent : 003C30; suivant : 003C32One‐Hz repetitive transcranial magnetic stimulation of the premotor cortex alters reciprocal inhibition in DYT1 dystonia
Auteurs : Ying-Zu Huang [Royaume-Uni] ; Mark J. Edwards [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; John C. Rothwell [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-01.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Carrier Proteins (genetics), DYT1, Dystonia, Dystonia Musculorum Deformans (genetics), Dystonia Musculorum Deformans (physiopathology), Dystonia Musculorum Deformans (therapy), Dystonic Disorders (genetics), Dystonic Disorders (physiopathology), Dystonic Disorders (therapy), Electric Stimulation, Electromyography, Evoked Potentials, Motor (physiology), Female, Forearm (innervation), H-Reflex (physiology), Hand (innervation), Heterozygote Detection, Humans, Male, Median Nerve (physiopathology), Middle Aged, Molecular Chaperones (genetics), Motor Cortex (physiopathology), Motor Neurons (physiology), Muscle, Skeletal (innervation), Nervous system diseases, Neural Inhibition (physiology), Neural Pathways (physiopathology), Premotor cortex, Radial Nerve (physiopathology), Reciprocal inhibition, Sensory Thresholds (physiology), Spinal Cord (physiopathology), Transcranial Magnetic Stimulation (therapeutic use), dystonia, rTMS, reciprocal inhibition.
- MESH :
- chemical , genetics : Carrier Proteins, Molecular Chaperones.
- genetics : Dystonia Musculorum Deformans, Dystonic Disorders.
- innervation : Forearm, Hand, Muscle, Skeletal.
- physiology : Evoked Potentials, Motor, H-Reflex, Motor Neurons, Neural Inhibition, Sensory Thresholds.
- physiopathology : Dystonia Musculorum Deformans, Dystonic Disorders, Median Nerve, Motor Cortex, Neural Pathways, Radial Nerve, Spinal Cord.
- therapeutic use : Transcranial Magnetic Stimulation.
- therapy : Dystonia Musculorum Deformans, Dystonic Disorders.
- Adult, Electric Stimulation, Electromyography, Female, Heterozygote Detection, Humans, Male, Middle Aged.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) can produce long‐lasting effects not only underneath the site of stimulation, but also at distant connected sites. This study aimed to assess how low frequency rTMS over the premotor area might affect abnormalities in spinal motor function in patients with generalised dystonia associated with the DYT1 gene mutation. We assessed reciprocal inhibition (RI) in a group of 8 manifesting carriers of the DYT1 gene (DYT1) and 10 healthy controls. All subjects then received 20 minutes of 1 Hz rTMS over the premotor area, and RI was assessed again. Before rTMS, the second and third phases of RI were abnormal in DYT1 subjects compared to controls. After 20 minutes of 1 Hz rTMS over the premotor area, a significant increase in inhibition was noted in the third and possibly the first phase of RI in the DYT1 group. No changes in RI were observed in control subjects after rTMS. We have shown for the first time to date that reducing cortical excitability in patients with dystonia using rTMS can produce corresponding changes in abnormal spinal motor output. These findings make a case for further exploring rTMS as a tool to modulate abnormal cortical and spinal excitability in individuals with dystonia and even as a potential form of treatment for dystonic symptoms. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10627
Affiliations:
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Le document en format XML
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Edwards</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-01">2004-01</date><biblScope unit="vol">19</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="54">54</biblScope><biblScope unit="page" to="59">59</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">582BBE64EC10655CCC91C27767FA9BBE4D5ED511</idno><idno type="DOI">10.1002/mds.10627</idno><idno type="ArticleID">MDS10627</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Carrier Proteins (genetics)</term><term>DYT1</term><term>Dystonia</term><term>Dystonia Musculorum Deformans (genetics)</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Dystonia Musculorum Deformans (therapy)</term><term>Dystonic Disorders (genetics)</term><term>Dystonic Disorders (physiopathology)</term><term>Dystonic Disorders (therapy)</term><term>Electric Stimulation</term><term>Electromyography</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Forearm (innervation)</term><term>H-Reflex (physiology)</term><term>Hand (innervation)</term><term>Heterozygote Detection</term><term>Humans</term><term>Male</term><term>Median Nerve (physiopathology)</term><term>Middle Aged</term><term>Molecular Chaperones (genetics)</term><term>Motor Cortex (physiopathology)</term><term>Motor Neurons (physiology)</term><term>Muscle, Skeletal (innervation)</term><term>Nervous system diseases</term><term>Neural Inhibition (physiology)</term><term>Neural Pathways (physiopathology)</term><term>Premotor cortex</term><term>Radial Nerve (physiopathology)</term><term>Reciprocal inhibition</term><term>Sensory Thresholds (physiology)</term><term>Spinal Cord (physiopathology)</term><term>Transcranial Magnetic Stimulation (therapeutic use)</term><term>dystonia</term><term>rTMS</term><term>reciprocal inhibition</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term><term>Molecular Chaperones</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia Musculorum Deformans</term><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Forearm</term><term>Hand</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>H-Reflex</term><term>Motor Neurons</term><term>Neural Inhibition</term><term>Sensory Thresholds</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia Musculorum Deformans</term><term>Dystonic Disorders</term><term>Median Nerve</term><term>Motor Cortex</term><term>Neural Pathways</term><term>Radial Nerve</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dystonia Musculorum Deformans</term><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Electric Stimulation</term><term>Electromyography</term><term>Female</term><term>Heterozygote Detection</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cortex prémoteur</term><term>Dystonie</term><term>Inhibition réciproque</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Repetitive transcranial magnetic stimulation (rTMS) can produce long‐lasting effects not only underneath the site of stimulation, but also at distant connected sites. This study aimed to assess how low frequency rTMS over the premotor area might affect abnormalities in spinal motor function in patients with generalised dystonia associated with the DYT1 gene mutation. We assessed reciprocal inhibition (RI) in a group of 8 manifesting carriers of the DYT1 gene (DYT1) and 10 healthy controls. All subjects then received 20 minutes of 1 Hz rTMS over the premotor area, and RI was assessed again. Before rTMS, the second and third phases of RI were abnormal in DYT1 subjects compared to controls. After 20 minutes of 1 Hz rTMS over the premotor area, a significant increase in inhibition was noted in the third and possibly the first phase of RI in the DYT1 group. No changes in RI were observed in control subjects after rTMS. We have shown for the first time to date that reducing cortical excitability in patients with dystonia using rTMS can produce corresponding changes in abnormal spinal motor output. These findings make a case for further exploring rTMS as a tool to modulate abnormal cortical and spinal excitability in individuals with dystonia and even as a potential form of treatment for dystonic symptoms. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Huang, Ying U" sort="Huang, Ying U" uniqKey="Huang Y" first="Ying-Zu" last="Huang">Ying-Zu Huang</name></region><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Edwards, Mark J" sort="Edwards, Mark J" uniqKey="Edwards M" first="Mark J." last="Edwards">Mark J. Edwards</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. 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